Melatonin treatment in children with ADHD and chronic sleep onset insomnia

Melatonin treatment in children with ADHD and chronic sleep onset insomnia

Melatonin, also known as N-acetyl-5-methoxytryptamine, a hormone secreted by the pineal gland in the brain with functions of regulating sleep cycles, other hormones, timing in secretion of female hormones that affect the menstrual cycle, etc. The levels of the circulating hormone vary in a daily cycle, depending to the circadian rhythm is an internal 24-hour “clock”.

Melatonin treatment in children with ADHD and chronic sleep on set insomnia

In the study to assess long-term melatonin treatment course, effectiveness and safety in children with attention-deficit/hyperactivity disorder (ADHD) and chronic sleep onset insomnia (CSOI), researchers at the Department of Neurology, Elisabeth Hospital, Tilburg, The Netherlands, found that long-term melatonin treatment was judged to be effective against sleep onset problems in 88% of the cases. 

Improvement of behaviour and mood was reported in 71% and 61% respectively. We conclude that melatonin remains an effective therapy on the long term for the treatment of CSOI in children with ADHD and has no safety concerns regarding serious adverse events or treatment related co-morbidity. 

Discontinuation of melatonin treatment usually leads to a relapse of sleep on set insomnia and in resuming melatonin treatment, even after several years of treatment (24).

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Sources
(24) http://www.ncbi.nlm.nih.gov/pubmed/19486273

Posted by Kyle J. Norton at 6:06 AM

Link: http://medicaladvisorjournals.blogspot.ca/2012/12/melatonin-treatment-in-children-with.html?zx=89dd98a9ad2b2bf3